Effects of Hepatocyte Growth Factor on Proliferation and Migration of Human Colon Cancer Cells SW620

ObjectiveTo investigate the effects of Hepatocyte growth factor (HGF) on the proliferation and migration of SW620. Methods MTT was used to assess the effect of HGF on the proliferation of SW620.The effect of HGF on the migration of cells was calculated by restoration of basal membrane；the ultrastructure of SW620 after being treated with HGF was observed by TEM；the expression of MMP-2 was determined by PCR. Results HGF promoted both the proliferation and migration of SW620 in a dose-dependent manner.Microfilaments increased significantly after being treated with HGF.HGF up-regulated the expression level of MMP-2 mRNA of SW620 cells. Conclusion HGF can promote the proliferation and migration of colon cancer cell SW620.