Investigation of Dynamic Proportion Changes in Histopathological Types of Central Lung Cancer Diagnosed by Fiberopic Bronchoscope

ObjectiveIn the presently study, we investigated the dynamic changes of proportion in histopathological types of central lung cancer (CLC). MethodsThe illness tissue was adopted by forceps holder through bronchoscope and histopathological diagnosis was made after paraffin section and hematoxylin-eosin staining. The proportion changes of pathologic classification of lung cancer（LC） from 1987 to 2009 were investigated. ResultsFrom Junary,1987 to December,2009, there were 6 916 cases of lung cancer diagnosed by histopathology confirming via biopsy under bronchoscope,including 320,773,668,2 546 and 2 609 patients of lung cancer diagnosed in the periods of 1987-1991,1992-1996,1997-2001,2002-2006, 2007-2009,respectively. For these 5 periods of investigating times, the proportions of lung squamous cell carcinoma (LSCC) were 61.88%, 64.17%, 64.82%, 57.58%, 51.78%, of lung adenocarcinoma (LA) were 23.33%,18.50%,16.02%,18.03%, 25.41%, and of small cell lung cancer (SCLC) were 16.67%, 16.69%, 17.81%, 21.41%, 19.97%, respectively. The proportion of SCLC increased rapidly（P＜0.01). In the 5 periods according to times as previously, the female account for 7.07%, 8.06%, 11.32%, 5.39%, 7.40% in LSCC, 23.33%, 27.27%, 31.78%, 37.04%, 37.71% in LA, 16.67%, 19.38%, 13.45%, 18.53%, 17.66% in SCLC, respectively. Ascending trend in proportion was found in female LA（P＜0.05）. From 1987 to 2009, the average ages at the diagnosed point of 5 groups of LSCC were 56.07, 57.50, 56.15, 57.70, 58.66 years old, of LA were 53.97, 55.97, 53.51, 55.18, 55.72 years old, and of SCLC were 51.42, 53.74, 53.89, 55.00, 55.47. No aging tendency was found in the three main types of LC. ConclusionThe incidence rate of SCLC has been rising gradually. The LC incidence in female has been increasing since 1987, especially in female LA.