Effect of Curcumin on Proliferation and Apoptosis of Human Nasopharyngeal Carcinoma CNE-2Z Cells

ObjectiveTo study the effects of Curcumin on proliferation and apoptosis of human nasopharyngeal carcinoma cell CNE-2Z and its possible mechanism. MethodsAfter treatment with Curcumin at various concentrations, the proliferative inhibition of CNE-2Z was observed by MTT assay. The cell cycle influence and cell apoptosis rate were detected by flow cytometry. The expression of Bcl-2 and Bax were detected by Western blot. ResultsCurcumin could inhibit the proliferation of human nasopharyngeal carcinoma cells CNE-2Z at a time and dose dependent pattern.The cells were blocked at G2/M and S phases. When treated with Curcumin for 24h, the percentage of cell apoptosis was increased. Bcl-2 was down-regulated whereas Bax was up-regulated. ConclusionCurcumin could inhibit the proliferation of CNE-2Z and induce cell apoptosis.