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DAI Yi, LI Jing-dong, ZHAO Guo-gang, LIU Hui, LONG Juan, ZOU Lin. Correlative Expressions of β-arrestin1 and MMP-9 in Hepatocelluar Carcinoma Tissues[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 170-173. DOI: 10.3971/j.issn.1000-8578.2011.02.014
Citation: DAI Yi, LI Jing-dong, ZHAO Guo-gang, LIU Hui, LONG Juan, ZOU Lin. Correlative Expressions of β-arrestin1 and MMP-9 in Hepatocelluar Carcinoma Tissues[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 170-173. DOI: 10.3971/j.issn.1000-8578.2011.02.014

Correlative Expressions of β-arrestin1 and MMP-9 in Hepatocelluar Carcinoma Tissues

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  • Received Date: January 21, 2010
  • Revised Date: May 26, 2010
  • objectiveTo investigate the expressions and significance of β-arrestin1 and matrix metalloproteinase-9 (MMP-9) in hepatocecullar carcinoma patients. Methods The tumor tissues and tumor-adjacent tissues were simultaneously collected from 35 patients in operation with diagnosed hepatocellular carcinoma,which included 23 cases of phase Ⅱ and 12 cases of phase Ⅲ. And 15 non-tumor tissues were enrolled in this study as the normal control (NL group). Then the mRNA and protein expression of β-arrestin1 were detected by using quantitative real-time RT-PCR and Western blot respectively. The protein concentration of MMP-9 of these tissues was measured by ELISA. Results All the mRNA and protein expressions of β-arrestin1 were measured in the samples of normal liver tissues,HCC tumor and its adjacent tissues. Compared with the normal group and tumor-adjacent group,the mRNA and protein expressions of β-arrestin1 in HCC group of different clinical phases increased significantly (P<0.05). The expression level was increased with the advanced phases. The concentration of MMP-9,increased in HCC tumor tissues,was positively correlated with β-arrestin1 expreesion(P<0.05) . ConclusionThe expressions of β-arrestin1 significantly up-regulated in HCC tumor tissues,which was positively related to the concentration of MMP-9,indicating that they might be related to progression of hepartocecullar carcinoma and to be the diagnosis and therapy target of HCC.
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