Expression and Significance of PDGF-D and Its Receptor in Gastric Carcinoma Tissues

ObjectiveTo investigate the correlation between mRNA expression of PDGF-D and PDGFRβ and clinicopathological features in gastric cancer. Methods The reverse transcription-polymerase chain reaction（RT-PCR）technique was used to examine mRNA expression of PDGF-D and PDGFRβ in 58 paired specimens of gastric carcinoma and tissues adjacent carcinoma. Results The positive rates of PDGF-D mRNA and PDGFRβ mRNA（98.28%，87.93%）were higher in gastric cancer tissues than（72.41%,53.45%）in tissues adjacent carcinoma respectively. While the positive rate of PDGFRβmRNA was 72.41%,which was positively correlated with PDGF-D（r=0.40，P＜0.05）.PDGF-D expression was correlated with lymph node metastasis and relapse (P＜0.05).No correlation was found between PDGF-D and other clinicopathological features of gastric carcinoma(P＞0.05). Conclusion PDGF-D may play a crucial role in carcinogenesis,development，metastasis and relapse of gastric cancer. It can be used as prognostic markers of gastric cancer in clinical practice.