Relation between MTA1 and VEGF Combinative Expression for Prognosis in Osteosarcoma Patients after Chemotherapy

ObjectiveTo explore the role of metastasis associated protein-1 （Mta-1 ）and vascular endothelial growth factor（VEGF） expression in the occurrence and development of osteosarcoma after chemotherapy.And to investigate the relation between MTA1 and VEGF combinative expression and the prognosis in osteosarcoma patients after chemotherapy. MethodsSP immunohistochemical technique was used to detect the expression of MTA1 and VEGF in the residual tumor cells from 31 osteosarcoma patients after chemotherapy. Results There were statistical significance of MTA1 and VEGF combinative expression for the prognosis in osteosarcoma patients after chemotherapy. Conclusion Both negative of MTA1 and VEGF are better for the prognosis in osteosarcoma patients after chemotherapy. While positive expression for both of them means poor prognosis. The results indicate that Mta-1 and VEGF combinative expression could be used to assess the prognosis of patients with osteosarcoma after chemotherapy.