Expression and Clinical Significance of Annexin-1 in Lung Squamous Carcinoma Tissues

Abstract:Objective To investigate the expression and significance of Annexin-1(Anx-A1) mRNA and protein in lung squamous carcinoma tissues. Methods Quantitative real-time PCR (qRT-PCR) and Western blot were used to detect Anx-A1 mRNA and protein levels in 22 cases of lung squamous carcinoma and corresponding adjacent normal tissues. The relationship between expressional levels and pathological characters was analyzed. Results The expression levels of Anx-A1 mRNA and protein in lung squamous carcinoma were significantly higher than those in adjacent normal tissues. The expression level of Anx-A1 in poor differentiated tissues was higher than that in middle and high differentiation tissues of lung squamous cell carcinoma(P<0.05). No expression difference between stage Ⅲ tumor tissues and stageⅠ~Ⅱ tissues was detected (P>0.05). Conclusion Up-regulated expressions of Anx-A1 mRNA and protein in lung squamous cell carcinoma tissue might contribute to lung carcinogenesis.