Effect of Oxaliplatin Combined with Capecitabine(XELOX) Biweekly in Patients with Advanced Gastrointestinal Cancer

Objective To assess the efficacy and tolerability of oxaliplatin combination capecitabine (XELOX)biweekly in patients with advanced gastrointestinal cancer．Methods 46 patients with advanced gastrointestinal cancer were treated with oxaliplatin 80 mg／m2 ivgtt d1 in 2 hours and capecitabine(XELOX) 900～1000mg/m2 bid，po d1~10．14 days was one cycle．The effect was evaluated after four cycles．Results All cases were evaluated，4 cases were complete response and 24 cases were partial response．The overall response rate was 65.2%．The main adverse effects were grade Ⅰ-Ⅱ hematological toxicity，nausea and vomit，peripheral neuropathy and hand-foot syndrome．Conclusion The combination of capecitabine and oxaliplatin (XELOX) is an effective and better tolerated treatment in advanced gastrointestinal cancer and can yield promising clinical application．