Expression of OGFR mRNA in Invasive Ductal Carcinoma of Breast

Objective To elucidate the features of OGFR mRNA expression in invasive ductal carcinoma of breast. Methods RT-PCR was used to detect the expression of OGFR mRNA in benign epithelial proliferation and invasive ductal carcinoma tissues of breast. Results The expressing quantity of OGFR mRNA was significantly higher in benign epithelial proliferation than that in invasive ductal carcinoma tissues(P<0.01).There was no significant difference between the expression of OGFR mRNA and patient's ages，volumes and grades of tumor，the expression of ER，PR，C-erbB-2 and lymphatic metastasis(P>0.05). Conclusion The reduced level of OGFR mRNA may serve as a marker of breast invasive ductal carcinoma.The subnormal levels of OGFR mRNA may contribute to the progression of breast carcinoma.