Expression of bFGFR, COX-2 and MVD and Their Relationships with Invasion and Metastasis in Gastric Cancer

Objective To investigate the expression of the basic fibroblast growth factor receptor (bFGFR)， COX-2 and MVD and their relationships with invasion and metastasis in gastric cancer. Methods Tissue sections from 80 gastric cancer(GC) as experimental groups and tissue sections from 40 chronic gastritis tissue as control groups were examined using immunohistochemistry for the expression of bFGFR, COX-2 and CD34. Results The positivity rates of bFGFR and COX-2 were 50.0% and 52.5%, respectively,which were significantly higher than those in patients with chronic gastritis tissue(P<0.01).The expression of MVD was (46.9±2.2) and (26.2±2.3)(P<0.01),respectively.The high positive expression of three indexes had correlation with regional invasion and lymphatic and remote metastasis in GC(P<0.05). But the expression has no correlation with the size and differentiation degree (P>0.05). The MVD values in bFGFR positive (48.7±10.2) and COX-2 positive (49.6±11.6)groups was significantly higher than those in bFGFR negative and COX-2 negative groups(33.6±5.2 and 32.7±4.5, P<0.01).The expression of bFGFR was significantly positively correlated with COX-2（γ=0.700，P=0.0000）. Conclusion The expression of bFGFR,COX-2 and MVD might be significantly correlated with invasion and metastasis of gastric cancer. The three indexes together may play coordinate role in vascularization. The positive expression of three indexes will be important diagnosis index in gastric cancer growth and metastasis.