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XIAO Jian-jun, PENG Jie-wen, HE Jing-huan, JIANG Xiao-mei, HE Jie-bing. Effects of Chemotherapy on T-lymphocyte Subgroups in Patients with Advanced Colorectal Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(08): 931-934. DOI: 10.3971/j.issn.1000-8578.2010.08.019
Citation: XIAO Jian-jun, PENG Jie-wen, HE Jing-huan, JIANG Xiao-mei, HE Jie-bing. Effects of Chemotherapy on T-lymphocyte Subgroups in Patients with Advanced Colorectal Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(08): 931-934. DOI: 10.3971/j.issn.1000-8578.2010.08.019

Effects of Chemotherapy on T-lymphocyte Subgroups in Patients with Advanced Colorectal Cancer

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  • Received Date: June 17, 2009
  • Revised Date: February 22, 2010
  • Objective:To explore T-lymphocyte subgroups immune function of advanced colorectal cancer patients and its clinical significance. Methods:The change of T-lymphocyte subgroups was measured with flow cytometry before and after treatment in the patients with advanced colorectal cancer compared with the healthy control group. Results:The 84 cases of advanced colorectal cancer in patients with T-lymphocyte subgroups compared with 35 cases of normal control group, CD4+,CD8+CD28+,CD28+ were significantly lower than the control group (P<0.01), CD8+CD28- was higher than control group (P<0.01),CD3+,CD8+,CD4+/CD8+ ratio were no significant difference compared with the control group(P>0.05).The 69 cases were respected chemotherapy,clinical benefit of 39 cases,after chemotherapy,CD3+ were higher than that in pre-treatment (P<0.05), CD8+,CD8+CD28- were significantly lower (P<0.01), CD4+,CD8+CD28+、CD28+,CD4+/CD8+ ratio were significantly higher (P<0.01); clinical ineffective of 30 cases, after chemotherapy, CD8+、CD8+CD28- were significantly higher than that in pre-treatment (P<0.01), CD4+、CD4+/CD8+ ratio were significantly lower (P<0.01), CD28+ were lower (P<0.05), CD3+、CD8+ CD28+were lower,but no significant difference (P>0.05). Conclusion :The immunity was suppressed in the patients with advanced colorectal cancer and immunity of the patients can be improved by effective chemotherapy.So clinical observation to the T-lymphocyte subgroups expression,in particular the joint detection CD8+CD28+、CD8+CD28-、CD28+Tcells to assess advanced colorectal cancer cells in patients with immune function and disease is more positive clinical significance.
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