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ZHANG Yi-qun, YE Shuang-mei, JIANG Xue-feng, JI Li, WEI Jun-cheng, WANG Hui, LU Yun-ping, XI Ling. Expression of Prox1 in Human Breast Cancer and Its Relationship with Tumor Lymphatic Metastasis[J]. Cancer Research on Prevention and Treatment, 2010, 37(07): 777-780. DOI: 10.3971/j.issn.1000-8578.2010.07.012
Citation: ZHANG Yi-qun, YE Shuang-mei, JIANG Xue-feng, JI Li, WEI Jun-cheng, WANG Hui, LU Yun-ping, XI Ling. Expression of Prox1 in Human Breast Cancer and Its Relationship with Tumor Lymphatic Metastasis[J]. Cancer Research on Prevention and Treatment, 2010, 37(07): 777-780. DOI: 10.3971/j.issn.1000-8578.2010.07.012

Expression of Prox1 in Human Breast Cancer and Its Relationship with Tumor Lymphatic Metastasis

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  • Received Date: March 16, 2009
  • Revised Date: August 29, 2009
  • Objective:To investigate the expression of Prox1 in human breast carcinoma and its relationship with clinical pathologic characters. Methods :The expression of Prox1 was detected by SP immunohistochemistry in 11 specimens of hyperplasia of mammary glands,80 specimens of breast cancer (30 with lymphatic metastasis). Results :The expression of Prox1 in 11 specimens of hyperplasia of mammary glands was completely negative,but were 62.5%(50/80)of the carcinoma nests cells and 65.0%(52/80)of lymphatic endothelial cells in breast cancer specimens.The percentage of cells positive for Prox1 in breast cancer patients with metastasis (76.7%, 23/30) was higher than those without (54.0%, 27/50), as well as in lymphatic endothelial cells with metastasis (83.3%, 25/30) than those without (54.0%, 27/50).The differences of two groups have statistical significance (P<0.05).The expression of Prox1 in the lymphatic endothelial cells of lymphatic metastasis specimens was correlated with the numbers of invaded lymph nodes (P<0.05).However, no significant correlation was found between Prox1 expression level and the following clinical parameters: age, ER status, PR status, HER2 status(P>0.05).Positive correlation(r=0.452, P<0.001)of the Prox1 expression was found between carcinoma cells and lymphatic endothelial cells, and Prox1 expression in carcinoma cells and lymphatic endothelial cells were both positively correlated with TNM stage(r=0.589, P<0.001). Conclusion :The high expression of Prox1 may be correlated with the process of breast cancer progression and metastasis.
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