Correlation between MSCT Perfusion Parameters and MVD in Astrocytic Tumor

Objective To evaluate the relationship among CTP parameters and MVD in astrocytic tumor. Methods Fifty-three patients with brain tumors underwent CTP examination, and the astrocytic tumors confirmed by operation and pathology were selected as the object of this study. The main observation contents included the maximum perfusion regional CTP parameters and MVD in tumor areas, and the CTP parameters of normal brain tissue in opposite side. Results CBF, CBV, PS and MVD were significant higher in both high and low grade astrocytic tumors, compared with normal brain tissue in opposite side (P<0.01), while MTT result were not significantly different (P>0.05). The CBF, CBV and PS values were strongly and positively correlated with tumor MVD in astrocytic tumors. Pearson correlations, were as follows: CBF and MVD, r＝0.819, P<0.01; CBV and MVD, r＝0.862, P<0.01; PS and MVD, r＝0.776, P<0.01. Hawever, MTT results were not correlated with MVD (r＝-0.320, P>0.05). Conclusion The CBF, CBV and PS values of multi-slice CTP are able to quantitatively and accurately reflect the angiogenesis of astrocytic tumors.