Expression of Cyclooxygenase-2 (COX-2)in Human Transitional Cell Carcinoma of Bladder and Its Relationship with HER-2 and p53

Objective To investigate the expression of COX-2, HER-2 and p53 in human transitional cell carcinoma of the bladder and their possible correlation. Methods SP immunohistochemistry staining was performed to evaluate the expression of COX-2, HER-2 and p53 in 56 cases of transitional cell carcinoma of the bladder and 10 cases of normal bladder mucosa. Results (1)The positive expression ratio of COX-2, HER-2 and p53 was 57.1%（32/56），51.8%（29/56）and 50%（28/56）, respectively. The difference between carcinoma group and normal tissues group was statistically significant ( P <0.05). The expression of all above genes was related to clinic stage and the tumor grade ( P <0.05). (2) The expression of HER-2 and p53wassignificant correlation with the expression of COX-2 ( P <0.05). Conclusion The abnormal expression of COX-2, HER-2 and p53 might play a certain role in course of the occurrence, development of transitional cell carcinoma of the bladder. The over-expression ofCOX-2 in transitional cell carcinoma of the bladder was correlated with the expression of HER-2 and p53.