Experiment of Anti-MA Lymphoma of Mice by Fludarabine Peritoneal Injection Associated with Inactivated Lymphoma Vaccine

Objective：To observe the anti- RMA lymphoma effect and mechanism by Fludarabine injection associated with inactivated lymphoma vaccine. Methods：Use C57BL/6 mice as a target, Foxp3 genes in spleens were identified by Western blot, at the same time, the tumor growth and survival of the Fludarabine group and the control group were observed. Results：Fludarabine could downregulate the expression of Foxp3 gene，and fludarabine associated with vaccine could not only inhibit the tumor growth but also improve survival of animals ( P <0.05). Conclusion：The experiment revealed that Fludarabine associated with vaccine can strengthen the ability to antagonize tumor, and prolog life span of tumor-bearing mice.