Expression of p-mTOR，GST-π and Ki-67 in Human Esophageal Squamous Cell Carcinomas and Their Correlations

Objective To study the relationship of the expression of p-mTOR，GST-π and Ki-67 and their correlations in esophageal squamous cell carcinomas(ESCC). Methods The expression of p-mTOR,GST-π and Ki-67 was detected by SP immunohistochemical staining in ESCC. Results The positive expression rates of p-mTOR,GST-π and Ki-67 were 20.8%,25%,62.5% in well-differentiated group, 39.1%,45.7%,65.4% in moderately differentiated group and 66.7%,72.2%,94.4% in poorly differentiated group respectively. Significant correlation was found between the expression of p-mTOR and GST-π in ESCC （r_s=0.797，P<0.01）, while no correlation was detected between p-mTOR and Ki-67（r_s=0.126，P>0.05）. Conclusion The expressions of p-mTOR, GST-π and Ki-67 correlate significantly with ESCC differentiation.The expression level of GST-π correlates with p-mTOR significantly.Thus the subset of patients with p-mTOR positive may potentially benefit from p-mTOR inhibiting therapy.