Expression of Matrix Metalloproteinase-24 in Ovarian Serous Cystadenocarcinoma Cell Lines

Objective To investigate the expression of matrix metralloproteinase-24 (MMP-24) gene and MMP-24 protein in ovarian serous cystadenocarcinoma cell lines. Methods The expression of MMP-24 gene and MMP-24 protein of human ovarian serous cystadenocarcinoma cell lines HO-8910、OVCa-R₃、SKOV₃ were analyzed with RT-PCR and Western blot respectivly. Results High levels of MMP-24 gene and MMP-24 protein were observed in ovarian carcinoma cell lines HO-8910、OVCa-R₃、SKOV₃,which were significantly higher than those in normal ovarian cells. Conclusion The MMP-24 gene possibly have an important association with the occurrence and development in ovarian carcinoma.