Clinical Significance andExpression of MUC4 and MUC16 in Ovarian Tumor

Objective To investigate the expression and clinical significance ofMUC4 and MUC16 proteins in epithelial ovarian carcinoma. Methods Primary ovarian epithelial cancer, borderline epithelial tumor, benign epithelial tumor and normal ovarian tissue were detected and analyzed for their MUC4 and MUC16 protein expression level with immunohistochemical method. The paraffin-embedded tissue sections were incubated with anti- MUC4 antibody and anti- MUC16 antibody. Results The positive rate of MUC4 protein and MUC16 protein expression in normal ovarian tissue, ovarian benign epithelial tumors,borderline epithelial tumors and malignant epithelial tumors was 0，10%，36%and 80% and 0，20%，54%and61% respectively. The statistical evaluation showed that the expression of MUC4proteinhad a close relation with histological differentiation and lymph node metastasis in epithelial ovarian carcinoma (P<0.05). Conclusion MUC4 protein was high expression in ovarian carcinoma, which meant that MUC4 is correlated with the growth and development of ovarian tumor.