Advanced Search
LIU Jing, SUN Ye-huan, CHEN Ying, CHEN Peng, HEI Jin-xuan, GENG Jiao, SUN Liang. Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Esophageal Cancer in Chinese Population: Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 213-217. DOI: 10.3971/j.issn.1000-8578.2010.02.024
Citation: LIU Jing, SUN Ye-huan, CHEN Ying, CHEN Peng, HEI Jin-xuan, GENG Jiao, SUN Liang. Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Esophageal Cancer in Chinese Population: Meta-analysis[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 213-217. DOI: 10.3971/j.issn.1000-8578.2010.02.024

Methylenetetrahydrofolate Reductase Polymorphisms and Susceptibility to Esophageal Cancer in Chinese Population: Meta-analysis

More Information
  • Corresponding author:

    SUN Ye-huan

  • Received Date: October 12, 2008
  • Revised Date: March 12, 2009
  • Objective To study the relationship between Methylenetetrahydrofolate reductase polymorphisms and susceptibility to esophageal cancer in Chinese populations by Meta-analysis. Methods Computer literature searching was carried out in CBM and PubMed database to collect the articles of the case-control studies on association between MTHFR polymorphism and susceptibility to esophageal cancer,also performed searching based on www.baidu.com and www.google.cn.Odds ratio was employed to evaluate the susceptibility to esophageal cancer and MTHFR status.Heterogeneity was checked by chi-square test.Publication bias was assessed by using a funnel plot and Egger's test. Results Ten papers were selected.Meta-analysis found that OR (95%CI) for polymorphisms of the MTHFRC677T and MTHFRA1298C were 1.97 (1.69,2.30) and 0.84 (0.66,1.08) respectively.Stratification analysis showed that OR for the MTHFRC677T and esophageal cancer among the smoke group was 2.57 (95%CI:1.73~3.80); OR for the MTHFRC677T and esophageal cancer among the non-smoke group was 1.33 (95%CI:0.94~1.88). Conclusion Polymorphisms of MTHFRC677T had statistically significant association between the MTHFR variants and susceptibility to esophageal cancer,MTHFRA1298C and esophageal cancer failed to show statistically significant association.The MTHFRC677T genotype with smoking might be associated with the increased risk of esophageal cancer.
  • Related Articles

    [1]HE Yang, YANG Runfeng, ZHOU Yingying, XU Qian, YAN Hao, JIANG Lei, JIANG Xiaohui, HUANG Yi. Effect of Aprepitant on Chemotherapy-induced Adverse Reactions in Gynecological Malignancy Patients[J]. Cancer Research on Prevention and Treatment, 2018, 45(11): 913-916. DOI: 10.3971/j.issn.1000-8578.2018.18.0265
    [2]LI Daojun, XU Xinhua, ZHANG Jianyu, LI Cong. Clinical Observation of Olanzapine in Treatment of Nausea and Vomiting Caused by Opioid Analgesics[J]. Cancer Research on Prevention and Treatment, 2018, 45(5): 326-328. DOI: 10.3971/j.issn.1000-8578.2018.17.1275
    [3]DONG Shuang, WANG Jun, HU Sheng, LIAO Guoxiang, RAN Fengming. Aprepitant versus Olanzapine for Prevention of Nausea and Vomiting Induced by Multi-day Chemotherapy in Female Lung Cancer or Breast Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2017, 44(5): 356-359. DOI: 10.3971/j.issn.1000-8578.2017.05.009
    [4]LI Quanfu, Jin gaowa, WANG Wenjuan, JIANG Caihong, DENG Shuqin, LI Hui, CHEN Feng, BAI Xiaojun, CHEN Gang, HU Yuliang, ZHAO Jun, Dalenggaowa, Wuyungaowa. Clinical Observation of Neurokinin-1 Antagonist Preventing Multiple-day Chemotherapy-induced Nausea and Vomiting[J]. Cancer Research on Prevention and Treatment, 2017, 44(4): 290-294. DOI: 10.3971/j.issn.1000-8578.2017.04.011
    [5]LV Minhao, QIN Li, LI Juntao, GUO Xuhui, LIU Fawen, CUI Shude, ZHANG Hengwei. 原发性乳腺癌分子分型与新辅助化疗疗效及预后的相关性[J]. Cancer Research on Prevention and Treatment, 2015, 42(08): 782-788. DOI: 10.3971/j.issn.1000-8578.2015.08.007
    [6]DONG Shuang, YU Shiying. A Study of Chemotherapy-induced Nausea and Vomiting Involving Different Dosage Regimens of Cisplatin[J]. Cancer Research on Prevention and Treatment, 2013, 40(09): 890-893. DOI: 10.3971/j.issn.1000-8578.2013.09.016
    [7]Xu Lu, Li Chunlai, Li Ling. A Constructive Experimental Study on Prevention of Chemotherapy-induced Nausea and Vomiting by Ginger-partitioned Moxibustion on Acupoint of Zusanli[J]. Cancer Research on Prevention and Treatment, 2012, 39(06): 710-712. DOI: 10.3971/j.issn.1000-8578.2012.06.024
    [8]XU Shu, LI Hong, SONG Yu-hong, LI Bin, CAI Hong-bing. Clinical Comparative of Tropisetron Hydrochloride with or without Traditional Chinese Medicine Compound in Prevention of Chemotherapy-induced Nausea and Emesis[J]. Cancer Research on Prevention and Treatment, 2009, 36(09): 787-790. DOI: 10.3971/j.issn.1000-8578.2009.09.021
    [9]MA Lei, MA Hai-long, ZHAO Xu-lin, et al. A Clinical Observation of Tropisetron in Combination with Dexame thasone and Methclopramide in the prevention of High Dose Cisplatin- induced Delayed Nausea and Emesis[J]. Cancer Research on Prevention and Treatment, 2001, 28(06): 469-470. DOI: 10.3971/j.issn.1000-8578.474
    [10]Chen Zhendong, . Medroxyprogesterone Acetate with Antiemetics: Efficacy in ControllingAnorexia, Nausea and Vomiting Induced by Chemotherapy[J]. Cancer Research on Prevention and Treatment, 1996, 23(2): 102-103.

Catalog

    Article views (2364) PDF downloads (535) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return