Investigation of Expression and Correlation of survivin and AURORA_B in Pancreatic Denocarcinoma Tissues

Objective To investigate the correlation between the expression of survivin and AURORA_B protein and their clinical biological behavior in human pancreatic carcinoma tissues. Methods SP immunohistochemical method was used to detect expression of survivin and AURORA_B in 45 cases of human pancreatic carcinoma tissues,8 cases of chronic pancreatitis tissues and 7 normal pancreas tissues. Results The positive expression rates of survivin and AURORA_B in 45 cases of pancreatic carcinoma tissues were 75.55% and 53.33%, respectively, and no expression of survivin and AURORA_B was found in the 7 cases of normal pancreas tissues. In addition, the expression rates of survivin and AURORA_B in 8 cases of chronic pancreatitis tissues were 25% and 0, respectively. The survivin expression was significantly correlated with the histological grade (P<0.05), but not with the clinical stages and lymph node metastasis (P>0.05). The AURORA_B expression was significantly correlated with the clinical stages and lymph node metastasis (P<0.05), but not with the histological grades(P>0.05). The expressions of survivin and AURORA_B had no correlation with age, gender, tumor size and location, however, the expression of survivin was closely correlated with that of AURORA_B (P<0.05). Conclusion survivin and AURORA_B were intimately related to pancreatic carcinoma. They may play an important role in the tumorigenesis and tumor progression in pancreatic cancer and provide some new targets for the therapy and prevention of pancreatic cancer.