Advanced Search
WANG Xiao-chun, TIAN Jing, WU Hai-liang, MENG Ai-min, MA Ting-hang, WANG Yue-ying, DU Li-qing, ZHANG Heng, WU Hong-ying, LI De-guan. Expressions of CKS1 and p27 in Breast Cancer and Their Significance[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 165-168. DOI: 10.3971/j.issn.1000-8578.2010.02.011
Citation: WANG Xiao-chun, TIAN Jing, WU Hai-liang, MENG Ai-min, MA Ting-hang, WANG Yue-ying, DU Li-qing, ZHANG Heng, WU Hong-ying, LI De-guan. Expressions of CKS1 and p27 in Breast Cancer and Their Significance[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 165-168. DOI: 10.3971/j.issn.1000-8578.2010.02.011
shu

Expressions of CKS1 and p27 in Breast Cancer and Their Significance

  • 1.Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China.; 2.Department of 4th Internal Medicine, Cancer Prevention and Treatment Institute of Shandong Province; 3.Department of Tumor Medicine, Shandong Provincial Chest Hospital

More Information
  • Received Date: October 13, 2008
  • Revised Date: March 26, 2009
    Graphical Abstract
    • Abstract
  • Objective To investigate the expression of CKS1 and p27 protein in breast cancer and analyze their correlation with clinical parameters. Methods Immunohistochemical staining method of SP was used to examine 149 samples of breast cancer. Results The expression of CKS1 in breast cancer was significantly associated with lymph node metastasis and clinical stage (P<0.05). No correlation was found between expression of CKS1 and tumor differentiation. Significantly inverse correlation was found between expression of p27 and lymph node metastasis (P<0.05). Multivariate analysis showed statistical correlation between the prognosis and clinical stage, lymph node metastasis, expression of CKS1 and p27（P<0.01）. Significantly inverse correlation was found between CKS1 and p27 expression. Conclusion CKS1 and p27 may play an important role in breast cancer and could be the potential gene therapy target for breast cancer.
    • FullText(HTML)
    • References (0)
    • Related Articles

Catalog

    Get Citation
    PDF
    XML
    Article views (2142) PDF downloads (544) Cited by()
    Turn off MathJax
    Article Contents
    Abstract

    Download Center

    Links

    Contact Us

    Address：116 Zhuodaoquan South Road,
    Hongshan District, Wuhan（430079）

    Tel：027－87670126

    Email：zlfzyjzz@vip.163.com

    This work is licensed under a Creative Commons Attribution 3.0 License.

    Email Alert RSS
    Total visits：11643662 Visits today：11011

    Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return