Antiangiogneic Effect and Antitumor Effect of Minidose Xeloda on Mice with CT-26 Coloretical Carcinoma

Objective To evaluate the antiangiogenic effect and antitumor effect of the minidose Xeloda on the mice with coloretical carcinoma. Methods Sixteen Balbc mice modle with CT-26 coloretical carcinoma were established and randomized into two groups: Tested group (continues low dose Xeloda,90mg/kg) and control group（0.9% sodium chloride）.Then the size of tumor、weight of mice were observed. At the end of the experiment(2 weeks after modle making ), tumor tissue was given immunohistochemical staining. Tumor microvascular density (MVD) and vascular endothelial growth factor (VEGF) expression were detected, and VEGF expression was detected by Western blot. Results Compared with control group, tumor growth of tested group was obviously restrained. MVD and VEGF expression were decreased in tested group. There was no toxic reaction in tested group. Conclusion The continuous low dose of Xeloda played a role of antitumor by holding tumor vascularization. The possible mechanism is inhibiting the expression of VEGF.