Clinical Trial Report of TACE Combined with PLCT and PEIT in Treatment of Liver Cancer

Objective To assess the safety and effect of transarterial chemoembolization (TACE), associated with percutaneous local cryotherapy（PLCT）and percutaneous ethanol injection therapy (PEIT） in treating unresectable liver malignance, and compared with TACE combined with PEIT alone. Methods One hundred and thirty-two patients with unresectable HCC were enrolled in this study. Seventy-six patients underwent TACE associated with PLCT and PEIT (triple-modality group), 56 patients underwent TACE associated with PEIT alone (bi-modality group). Results Response rate(RR) (42.1% vs 17.9%), Clinical benefited rate (85.5％ vs. 69.6％) and Time to progress (TTP) (12w vs. 10w) between triple-modality and bi-modality group were statistically significant (P<0.05). 1-year survival rate was no significant difference (P>0.05). Conclusion TACE combined with PLCT and PEIT is more effective than TACE combined PEIT alone, is a rational safe and effective multi-modality treatment model for unresectable HCC and worth further attention.