Clinical Significance of Measuring CD146⁺ Activated T Lymphocyte in Peripheral Blood of Patients with Malignant Tumor

Objective To study the changes of cluster of differentiation antigen 146 positive (CD146+) T lymphocyte in peripheral blood of patients with malignant tumor and its clinical significance. Methods CD3＋CD146＋ T lymphocyte in peripheral blood was detected in 47 normal control and 188 patients with malignant tumor by flow cytometry，and the amount and proportion change of CD146＋ T lymphocyte in patients with malignant tumor were observed. Results （1）Compared with normal control, CD146+ activated T lymphocyte percentage(CD146＋T/T) of total tumor group，liver cancer group，lung cancer group，esophageal carcinoma group，breast cancer, gastric cancer and pancreatic cancer group were obviously higher(P<0.001). （2）Compared with normal control,the gross of T lymphocyte in peripheral blood of tumor group was reduced (P<0.001),and there was no difference in number of CD146+ T lymphocyte in peripheral blood similar (P>0.05).（3）There was negative correlation between CD146＋T percentage and T lymphocyte counts in peripheral blood of patients with malignant tumor(n=188，r=-0.297,P<0.001).（4）The percentage of CD146+T(CD146+T/T) was no significant difference between metastasis group and no metastasis group(P>0.05). Conclusion The percentage of CD146+ T lymphocyte in patients with tumor was increased， the changes may be an important aspect on antitumor immunoregulatory in malignant tumor patients.