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LI Qiu-fang, YANG Xiao-peng, YANG Rui-ling, WANG Jing, WU Yi-ming. CO-examination of WWOX and ErbB2 Protein in Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2009, 36(06): 487-489. DOI: 10.3971/j.issn.1000-8578.2009.06.010
Citation: LI Qiu-fang, YANG Xiao-peng, YANG Rui-ling, WANG Jing, WU Yi-ming. CO-examination of WWOX and ErbB2 Protein in Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2009, 36(06): 487-489. DOI: 10.3971/j.issn.1000-8578.2009.06.010
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CO-examination of WWOX and ErbB2 Protein in Non-small Cell Lung Cancer

  • 1.Clinical Department，Nursing College of Zhengzhou University,Zhengzhou 450052,China；2. Department of Neurology,The Second Affiliated Hospital of Zhengzhou University；3. Department of Pharmacy，The First Affiliated Hospital of He'nan University；4. Department of Respiratory Medicine， The First Affiliated Hospital of Zhengzhou University；5. College of Public Health of Zhengzhou University

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  • Received Date: May 20, 2008
  • Revised Date: June 26, 2008
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  • Objective To study the expression and significance of WWOX gene in non-small cell lung cancer and the relationship with ErbB2 protein. Methods WWOX protein expression was evaluated by immunohistochemistry in 50 squamous cell carcinomas,31 adenocarcinomas and 20 adjacent normal lung tissues, and its correlation with clinical and histopathologic characteristics and the expression of ErbB2 protein were analyzed. Results WWOX expression was absent/reduced in 72.8% of NSCLC,whereas it was normal in 80.0% of adjacent normal lung tissues.WWOX expression was strongly associated with tumor histology and histologic grade（P<0.05),the percentage of cases with absent/strongly reduced WWOX expression was higher in squamous cell carcinomas and in poorly differentiated tumors.The overexpression of ErbB2 was associated with TNM stage and Lymph node metastasis.Finally,WWOX expression was negatively related to the overexpression of ErbB2(r=-0.239，P<0.05). Conclusion The low expression of WWOX expression and the overexpression of ErbB2 can estimate the prognosis of NSCLC.
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