Advanced Search
NIU Rong, YANG Yong-zhu, BAI Qi-zhou, WANG Zhi-qiang, GOU Yun-jiu. Expression and Clinical Significance of E2F-1 and Rb Genes in Esophageal Squamous cell Carcinomma[J]. Cancer Research on Prevention and Treatment, 2009, 36(05): 419-421. DOI: 10.3971/j.issn.1000-8578.2009.05.016
Citation: NIU Rong, YANG Yong-zhu, BAI Qi-zhou, WANG Zhi-qiang, GOU Yun-jiu. Expression and Clinical Significance of E2F-1 and Rb Genes in Esophageal Squamous cell Carcinomma[J]. Cancer Research on Prevention and Treatment, 2009, 36(05): 419-421. DOI: 10.3971/j.issn.1000-8578.2009.05.016

Expression and Clinical Significance of E2F-1 and Rb Genes in Esophageal Squamous cell Carcinomma

More Information
  • Received Date: March 12, 2008
  • Revised Date: July 03, 2008
  • Objective To investigate the expressions of E2F-1 and Rb in the esophageal squamous cell carcinomma and approach the relationship between the genes and clinical pathology and the roles in the process of esophageal squamous cell carcinogenesis. Methods Immunohistochemistry was used to detect the expressions of E2F-1 and Rb in 60 cases of esophageal squamous cell carcinoma and 50 cases of normal esophageal tissue. Results The positive rate of E2F-1 expression was 73.3% in cancerous tissue, which was significantly higher than 36.0% in normal esophageal tissue(P<0.01). The expression of E2F-1 was closely associated with tumor stage, differentiation and lymph node invasion(P<0.05).The negative rate of Rb was 30.0%in cancerous tissue,which was significantly higher than 12.0% in normal esophageal tissue(P<0.05).The expression of Rb was closely associated with tumor differentiation and lymph node invasion(P<0.05),but not associated with tumor stage. The expressions of E2F-1 and Rb in esophageal squamous cell carcinoma was negatively correlated (r=0.395,P=0.02). Conclusion The overexpression of E2F-1 and decreased expression of Rb involve in the occurrence and development of esophageal carcinoma in some extent.
  • Related Articles

    [1]CAO Wenjing, WANG Yulin, ZHAI Yuqing, ZHANG Zongliang, YUAN Jiangshui, SONG Weiqing. Expression and Clinical Significance of MIS18BP1 in Bladder Cancer Tissues[J]. Cancer Research on Prevention and Treatment, 2024, 51(3): 163-168. DOI: 10.3971/j.issn.1000-8578.2024.23.1041
    [2]ZHANG Yuanyuan, FANG Zhaoqin, LIANG Chao. Screening of Genes Involved in Hepatoma Cells SMMC-7721 Stress Response Induced by Different Stressors[J]. Cancer Research on Prevention and Treatment, 2016, 43(6): 463-467. DOI: 10.3971/j.issn.1000-8578.2016.06.006
    [3]Pei Feng, Zhu Yi. Clinical Significance of Cytokeratin18 Fragments in Diagnosis of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(04): 439-441. DOI: 10.3971/j.issn.1000-8578.2012.04.018
    [4]YANG Guang-min, LI Shou-qing, MA Yin-fu, WEI Bing-bing, SHI Yang, TAN Yan. Anti-tumor Immunotherapy Effect of Co-expression Genetic Vaccine MAGE-1/IL-18[J]. Cancer Research on Prevention and Treatment, 2010, 37(03): 294-297. DOI: 10.3971/j.issn.1000-8578.2010.03.014
    [5]YANG Sheng, LU Hui-shan, CHEN Xiang-qi, LIN Ting-yan, LI Zhi-ying, KANG Ming-qiang. Effect of IL-18 on Growth and Apoptosis of Lewis Lung Cancer Xenografts in C57BL/6 Mice[J]. Cancer Research on Prevention and Treatment, 2009, 36(07): 563-565. DOI: 10.3971/j.issn.1000-8578.2009.07.007
    [6]ZHAO Hong-xia, WANG Yan-kui, LUO Bing, YIN Guang-jie. Influence of HPV18E6 Small Interfering RNA on p21,VEGF,Bax and Bcl-2 Genes in HeLa Cells[J]. Cancer Research on Prevention and Treatment, 2009, 36(04): 261-264. DOI: 10.3971/j.issn.1000-8578.2009.04.001
    [7]YANG Qin, CHEN Hong-lei, LIU Ming-qiu, FANG Zhong. PCR-SSCP Analysis of FADD Gene Mutation in Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2006, 33(03): 162-164. DOI: 10.3971/j.issn.1000-8578.442
    [8]GAO Yan-e, YANG Hui-ping, ZHANG Ju, GUO Jin-zhu, LIU Ning-xia, YAN Xiao-jun. Cloning and Sequencing of Human Papillomavirus Type 18 L1 Gene from Cervical Cancer Tissue[J]. Cancer Research on Prevention and Treatment, 2006, 33(03): 159-161. DOI: 10.3971/j.issn.1000-8578.441
    [9]LI Ji-mei, LI Chun-hai, WANG Qin-qin, et al, . Detect ion of MUC1 and GST-P Gene by means of RT-PCR in Axillary Lymph Nodes Taken from Breast Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2001, 28(05): 351-353. DOI: 10.3971/j.issn.1000-8578.1357
    [10]Luo YuanHui, . The Point Mutation of Ras and p53 Genes in Paraffin-embedded Gastric Cancer Tissues by PCR-RFLP Analysis[J]. Cancer Research on Prevention and Treatment, 1995, 22(2): 68-71.

Catalog

    Article views (2121) PDF downloads (380) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return