Effects of Extractive from Spina Gleditsiae (ESG)on Tumor Growth and Cytokines in Tumor-bearing Mice

ObjectiveTo study the effects of Extractive from Spina Gleditsiae (ESG)on the tumor growth and cytokines in tumor-bearing mice. MethodsAntitumor activity of ESG in vivo was observed by the models of implanted H22 or S180 cell line in mice. The expression of TNF-α、IL-2、IL-6 and IL-12 in tumor-bearing mice was detected by ELISA assay. Results At dosage of 50、100mg•kg-1,inhibitory rate of ESG is 44.59% and 53.38% for S180, 39.88% and 46.63% for H22, respectively. ESG can increase the expression of TNF-α、IL-2、IL-6 and IL-12. Conclusion ESG exhibits anti-tumor effect obviously in vivo and enhances immune function by promoting the expression of cytokine.