Report of Seven Cases of Kimura's Disease and Review of Literature

Objective To investigate the clinical pathology and diagnosis of Kimura's disease(KD). Methods Seven cases of KD were analyzed with clinical data, light microscopy and immunohistochemistry, meanwhile the different diagnosis were discussed referring literature. Results KD were occurred predominantly in males, and presented clinically as painless soft tissue masses in the head, neck and elbow regions. Its fundamental pathological changes were lymph foilicie hyperplasia accompanying with enlargement of Fleming's center, marked eosinophils infiltration, small vascular proliferation and interstitial fibrosis，and the co-expression of immunohistochemistry staining of κ and λ.All these indicated that KD is a disease of multiclonal accrementition. Conclusion KD is a agnogenic and specially inflamed process,and should be discriminated from Epithelioid Hemangioma.