Expression of PTTGand bFGF in Non2Hodgkin's Lymphoma

Objective 　To investigate the expression of PTTG and bFGF in non2hodgkin' s lymphoma and their significances. Methods 　Fif ty cases of N HL and twenty cases of benign lymphademopathy were studied. PTTG expression was measured at mRNA level by in2site hybridization ; PTTG and bFGF ex2 pression were measured at protein level by immunohistochemist ry. Results 　Positive expression rate of PTTG mRNA and it s protein in N HL was 54. 0 %(27/ 50) and 50. 0 %(25/ 50), respectively. Positive ex2 pression of them in N HL were significantly higher than those in the cont rol group . Positive expression rate of bFGF protein in NHL was 50. 0 %(25/ 50) . Positive expression of bFGF protein in NHL was sig2 nificantly higher than those in the cont rol. All expression grade of PTTG mRNA and it s protein, expres2 sion grade of bFGF protein were positively related to tumor histopathologic grade and clinical stage, re2 spectively. Expression of PTTG mRNA was positively related to the expression grade of PTTG and bF2 GF protein. There were both negative correlation between expression of PTTG mRNA and N HL recent effect s ; expression of bFGF protein and NHL recent effect s. Conclusion 　There was overexpression of PTTG and bFGF in N HL. Expression grade of PTTGor bFGF was related to NHL's clinicopathological parameters. PTTG might play an important role in the formation and development of N HL by means of increasing expression of bFGF directly or indirectly.