Albumin2Bound Particles in Treatment with Advanced Breast Cancer

Objective 　To compare the efficacy and the adverse reactions between albumin2bound particles and polyethylated castor oil2based paclitaxel in t reatment of advanced breast cancer. Methods 　Twenty2 one patient s were randomly divided into t reatment and cont rol group s with 32week cycles . The dose of t reatment group was 260 mg/ m2, which was 175 mg/ m2 in cont rol group . In cont rol group, dexametha2 sone, cimetidine and diphenhydramine were given before chemotherapy to prevent allergic reactions. Two groups of patient s received at least four cycles of t reatment, with assessment of every two cycles. Results In t reatment group, 9/ 9 cases were CR or PR, and in cont rol group was 7/ 12 cases. No allergic reactions in two group s. The main adverse reactions were neurotoxicity and neut ropenia. Conclusion 　By compare albumin2bound particles and polyethylated castor oil2based paclitaxel, the efficacy was similar, and in t reatment group, allergic reactions didn't occur without any preventive t reatment s of allergic reactions.