Cisplatin-Induced Apoptosis in Cisplatin-resistant Ovarian Cancer Cell Line A2780/DDP on Time- and Dose- Dependence
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Graphical Abstract
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Abstract
Objective To investigate the law during cisplatin-induced apoptosis in cisplatin-resistant and sensitive human ovarian cancer cell line A2780 and A2780/DDP and correlative protein expressions in mitochondria apoptotic pathway. Methods Two ovarian cancer cell lines,one is cisplatin-sensitive line A2780 and the other is resistant-line A2780/DDP,were selected.Based on cell culture,the influence of varied doses(5,10,20,40μM) and time(24,48,72h) of cisplatin on apoptosis in A2780 and A2780/DDP cell lines and prot...
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