The Expression of Podoplanin/VEGF-C and Lymph Node Metastasis in Human Colon Carcinoma
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Graphical Abstract
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Abstract
Objective This study was designed to investigate the relationship between Podoplanin and VEGF-C in human colon carcinomas and discuss the significance of Podoplanin、VEGF-C in lymph mode metastasis. Methods The expression of Podoplanin and VEGF-C in forty-eight colon carcinoma tissues and ten adjacent noncancerous specimens was evaluated by immunohistochemical analysis. Results (1) Podoplanin was overexpressed in 27 of 48 carcinoma tissues ( 56.3%) and VEGF-C was overexpressed in 31 of 48 ( 64.6%),which were s...
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