EGFR,COX-2 Expression Status and Microvessel Density Correlated to Prognosis in Early Stage Non-small Cell Lung Cancer

Objective We studied the association between the expression of epidermal growth factor receptor(EGFR), Cyclooxygenase-2 (COX-2), microvessel density(MVD) and disease free survival in early stage non-small cell lung cancer (NSCLC). Methods Thirty-six patients with NSCLC undergoing complete surgical resection were evaluated retrospectively. Tumor specimens were stained for EGFR, COX-2 and specific MVD marker(CD34) by Immunohistochemistry. Results EGFR and COX-2 over expressions were demonstrated in 44% and 53% ...