Clinical Observation of EP,DP Regimen Combined with Radiotherapy in Treatment of Locally Advanced Non-small Cell Lung Cancer

Objective To observe the effect and the clinical toxicity between EP,DP regimen combined with concurrent radiotherapy in the treatment of locally advanced non-small cell lung cancer(NSCLC). MethodsNinety-one patients were randomly assigned into two groups .EP group:EP regimen concurrent radiotherapy for 46 cases, DP group: DP regimen concurrent radiotherapy for 45 cases, radiotherapy are conventional standard fractionation. Results The response rate in EP group and DP group were 52.2%,71.1% respectively(P>0. 05) . The local complete response rate were 10. 9 %(5/ 46), 28. 9 %(13/ 45) for the patient s t reated with EP, DP regimen respectively ( P < 0. 05) . One year survival rate in EP, DP group were 45. 3 %, 62. 4 % respectively. Two year survival rate wrer 20. 2 % and 32. 6 %. The major toxicity was gast rointestinal t ract reaction, myelosuppression and alopecia and so on. Most of patient s tolerate well . Conclusion 　EP, DP regimen concurrent radiotherapy has good clinical efficacy and safe in the combined therapy of locally advanced NSCLC. They could become the original regimen in locally advanced NSCLC.