Preliminary Analysis of Tyrosine Kinase Signaling Pathway in Different Prognosis Patients with Lung Adenocarcinoma

Objective 　To study the abnormity of tyrosine kinase signaling pathway in different prognosis patients with lung adenocarcinoma. Methods 　We chose two patients, one's survival time was more than 60 months, the other's only 9 months. Total RNA was extracted form the two lung adenocarcinoma samples and their matched normal tissues, and then hybridized on the microarray with 13824 genes. At last their expression profiles of tyrosine kinase signaling pathway were analyzed by computer. Results 　The tyrosine kinase signaling pathway between L (the patient with the best prognosis) and S (the worse one) was very different . The most different was that S overexpressed some genes related to proliferation ( such as fms、K-ras、myc and so on ) while the genes related to immunity and anti-proliferation were in a low lever, for example, INFγ signaling pathways were inhibited, but which in L were activated. Some genes related to proliferation ( PDGF and it s recepter, H-ras, MAPK,etc. ) were overexpressed in S but low expressed in L. Conclusion 　In the complex system of tyrosine kinase signaling pathway in lung adenocarcinoma, different prognosis samples have different characteristic genes. In our research, the patient with the best prognosis overexpressed some genes related to immunity and anti-proliferation, and the worse one overexpressed some genes related to proliferation while the genes related to immunity and anti-proliferation were in a low lever.