1,4-phenylenebis selenocyanate exerts chemopreventive activity in rat tongue carcinogenesis

Objective To observe and study the inhibitory effects of dietary 1,4-phenylenebis elenocyanate on the formation of neoplasms of the rat tongue induced by 4-nitroquinoline-1-xide(4NQO). Methods During the initiation phase and the postinitiation phase of carcinogen exposure, 1,4-henylenebis selenocyanate was administraced in diet, observe the incidence of lesions, expression of cell proliferation biomarkers and enzymic activities by histopathology, immunohistochemic, spectrographic assays and high-pe...