Deletion and 5'CPG island Methylation of p15 Gene in Brain Glioma

Objective To investigate the abnormality of p15 gene in brain glioma and the correlation or it with occurrence or malignant progression of brain glioma. Methods Deletion and 5′CPG island methylation of p15 gene were detected by methods of PCR and PCR based methylation in 56 cases of brain glioma. Results Out of the 43 cases of high grade glioma,14 cases were found to have homozygous deletion of p15E1,while none of the 13 cases of low grade glioma was found to have deletion of p15E1 (P<0.05) .Methylati...