Preliminary Investigation of Expression of The Tumor Susceptibility Gene TSG101 in Sarcoma

Objective 　To detect the expression of the tumor susceptibility gene TSG101 in sarcoma to investigate the potential role of TSG101 in the pathogenesis of sarcoma. Methods 　40 formalin fixed and paraffin embeded sarcoma tissues were stained by HE and immunohistochemist ry to observe the expression of TSG101. Results 　The expression of TSG101 showed low level in sarcomas, with only 17. 5 % positive rate. Conclusion 　The defect of tumor susceptibility gene TSG101 appeared to be a f requent event in cancers derived f rom mesenchymal tissues. The different expressing rate of TSG101 in sarcomas and carcinomas implied a potential marker for differential diagnosis between them.