The Chemotherapy Sensitivity and Gene Expression in Lung Cancer Cell Lines

SONG Xian-rang; WEI Ling; WANG Xing-wu; LIU Xian-xi

doi:10.3971/j.issn.1000-8578.1573

SONG Xian-rang, WEI Ling, WANG Xing-wu, LIU Xian-xi. The Chemotherapy Sensitivity and Gene Expression in Lung Cancer Cell Lines[J]. Cancer Research on Prevention and Treatment, 2006, 33(01): 1-4. DOI: 10.3971/j.issn.1000-8578.1573

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The Chemotherapy Sensitivity and Gene Expression in Lung Cancer Cell Lines

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Objective To explore the relationship of chemotherapy sensitivity and expression of multidrug resistance genes and apoptosis regulation genes in human lung cancer cell lines. Methods MTT method was used to detect the sensitivity on adriamycin(ADM),cisplatinum(DDP), mitomycin C(MMC), fluorouracilum(5-Fu),carmustine(BCNU) in five lung cancer cell lines including SPCA1、NCI-H446、 SH-77、95C and 95D. Multidrug resistance genes including P-glycoprotein(P-gp), Glutsthione-s-transferases-π (GST-π), Lung resistance pr...

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The Chemotherapy Sensitivity and Gene Expression in Lung Cancer Cell Lines

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