Relationship between CYP2C9 and GST M1 Genetic Polymorphism and Lung Cancer Susceptibility

Objective To evaluate the relationship between CYP2C9, GST M1 genetic polymorlism and susceptibility of lung cancer. Methods The polymerase chain reaction-restriction fragment length polymorphlism (PCR-RFLP) was used to detect CYP2C9 genotype in 56 lung cancer cases and 42 controls. The PCR was also used to detect GST M1 genotype in the two groups. Results The frequencies of mutation genotype of CYP2C9*3 was not significant difference between lung cancer cases and controls.However, in the lung cancer cases, ...