The Activation of NF-κB Signaling Transduction Pathway in Esophageal Squamous Cell Carcinoma Cell Lines

Objective More and more evidences have shown that transcription factor Nuclear Factor-kappaB (NF-κB) plays a critical role in the initiation and progression of carcinogenesis. In the present study, we investigated whether the NF-κB signaling transduction pathway was constitutively activated in ESCC cell lines. Methods Immunocytochemistry and Western blotting were used to determine the protein levels of the subunits of NF-κB,p50 and p65, inhibitor-κBα and IKKβ in two ESCC cell lines. Nuclear proteins from the...