An Experimental Study of Paclitaxol on Inhibiting Angiogenesis

Objective To investigate the antiangiogenesis ability of Paclitaxel. Methods Human umbilical vein endothelial cells were cultured primarily in vitro and influence of Paclitaxel on HUVEC proliferation was evaluated by MTT method. Chick chorilallantoic membranes(CAM) model was used to check whether the neovascularization of CAM could be suppressed in vivo. Results Paclitaxel both inhibited proliferation of HUVEC in vitro and suppressed angiogenesis of CAM in vivo at none-cytotoxic doses. Conclusion Paclit...