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DU Cai-wen, LI De-rui, LIN Ying-cheng, et al. The effect of differentiation and related genes expression in human nasopharyngeal carcinoma xenograft induced by arsenic trioxide[J]. Cancer Research on Prevention and Treatment, 2003, 30(05): 382-384. DOI: 10.3971/j.issn.1000-8578.1436
Citation: DU Cai-wen, LI De-rui, LIN Ying-cheng, et al. The effect of differentiation and related genes expression in human nasopharyngeal carcinoma xenograft induced by arsenic trioxide[J]. Cancer Research on Prevention and Treatment, 2003, 30(05): 382-384. DOI: 10.3971/j.issn.1000-8578.1436
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The effect of differentiation and related genes expression in human nasopharyngeal carcinoma xenograft induced by arsenic trioxide

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  • Objective To investigate the morphological differentiation of human nasopharyngeal carcinoma in BALB/C nude mice induced by As_2O_3 and the roles of p53, bc1-2 and bax in this process. Methods After establishment of CSNE-1 xenograft model in nude mice, As_2O_3 was given at a dose of 5mg/kg intraperitoneally. The tumor growth of xenograft was observed after drug administration. The tumor tissues were examined by light and electron microscopy, nick-laelling(TUNEL), and immunohistochemistry technique. Result...
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