Expression of p16 and cyclin D_1 protein in peripheral blood of patients with bladder cancer

Objective To investigate the expression of p16 and cyclin D_1 protein in peripheral blood of bladder cancer. Methods p16 and cyclin D_1 protein were determined with flow cytometry in 47 cases bladder cancer and 20 cases normal control. Results The levels of p16 were ( 2.48 ± 0.91 )% in cancer group and ( 7.49 ± 5.22 )% in control group. While the levels of cyclin D_1 were ( 12.48 ± 9.27 )% and ( 0.66 ± 0.5 )%. Mean value of p16 in the cancers were lower than that in the controls ( P < 0.01 ),...