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GUO Lu, WEI Hu-lai, ZHANG Ya-li, LIU jian-min. Vitamin E Succinate Overcomes Apoptosis Resistance in Multidrug-resistant K562/ADM Cells by Down-regulating Expression of mdr1 Gene and Its Product P-glycoprotein[J]. Cancer Research on Prevention and Treatment, 2006, 33(09): 638-641. DOI: 10.3971/j.issn.1000-8578.1324
Citation: GUO Lu, WEI Hu-lai, ZHANG Ya-li, LIU jian-min. Vitamin E Succinate Overcomes Apoptosis Resistance in Multidrug-resistant K562/ADM Cells by Down-regulating Expression of mdr1 Gene and Its Product P-glycoprotein[J]. Cancer Research on Prevention and Treatment, 2006, 33(09): 638-641. DOI: 10.3971/j.issn.1000-8578.1324
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Vitamin E Succinate Overcomes Apoptosis Resistance in Multidrug-resistant K562/ADM Cells by Down-regulating Expression of mdr1 Gene and Its Product P-glycoprotein

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  • Objective To explore the apoptotic effect of Vitamin E succinate(VES) on multidrug-resistant leukemia K562/ADM cells and the possible molecular mechanisms. Methods Human multidrug-resistant leukemia cell line K562/ADM overexpressing mdr1 gene was used as the target cells. The cell proliferating activity was assessed with a MTT colorimetric assay. The apoptosis of K562/ADM cells was investigated by optical and electronic microscopic morphology and Annexin V/PI staining. The expression of mdr1 and Caspase-3 m...
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