The Preliminary Observation of Trastuzumab-based Combination Chemotherapy in Salvage Treatment of Her-2 Overexpressing in Metastatic Breast Cancer

Objective To observe the effects and toxicity of trastuzumab-based combination regimen comprising vinorelbine,fluorouracil and cisplatin in 15 patients with Her-2 positive metastatic breast cancer. Methods Treatment consisted of Trastuzumab(4mg/kg on day 0,then 2mg/kg weekly);vinorelbine (25mg/m2 on day 1 and 5);cisplantin(20mg/m2 on day 1～3) and fluorouracil (5-Fu) 1.0 on day 1～3. Results The overall response rate was 73%,including 6 complete( 40.0%) and 5 partial responses(33%).Median survival was 13 months...