Expressions of FHIT and PTEN in Brain Gliomas

Objective 　To examine the expressions of FHIT and PTEN in gliomas, and to investigate the relationship between their expressions and the degree of tumor malignancy. Methods 　SP Immunohistochemical staining was used to examine the expressions of FHIT, PTEN in 80 gliomas and in 5 normal brain tissues. Results 　FHIT was located in the plasma of glioma cells, PTEN was located in the cellular nuclei of glioma cells, total positive rates were 47. 5 % (38/ 80), 55. 0 % (44/ 80) respectively. Expression rates of FHIT and PTEN in normal brain tissues were 80 % (4/ 5) . There was a statistically significant difference in the expression of FHIT and PTEN between normal brain tissues and different grades of gliomas ( P < 0. 05) . Both of the expressions of FHIT and PTEN weakened with the rise in the degree of glioma malignancy. Conclusion 　Expressions of FHIT and PTEN in glioma cells are diminishing or absent, their cooperative operation promotes generation and advance of glioma.