Loss of fragile histidine triad protein expression in esophageal carcinoma

Objective To investigate the expression of fragile histidine triad protein, Fhit and the possible relationship between Fhit expression and clinicopathological indices in esophageal carcinoma. Methods Detecting Fhit protein expression in 53cases of esophageal carcinoma and analysing its relationship to histological grade and clinical stage by immunohistochemical method. Results The expression of Fhit protein was positive in 23/53 (43.4%) cases of cancer tissue and in 47/53 (88.7%) cases of adjacent non-tu...