Relationship of the Expression of MMP-2 、MMP-9 、TIMP-1 with Lymph Node Metastasis and Survival Time in Gastric Adenocarcinoma

Objective 　To study the expression of MMP-2, MMP-9 and TIMP-1 in gastric adenocarcinoma. Methods 　Tissue microarray of 136 gastric adenocarcinoma was const ructed by using a microarrayer. The expression of MMP-2, MMP-9 and TIMP-1 was detected on the section of tissue microarray by immuno-histochemistry. Results 　The positive rate of the expression of MMP-9 was 76 % in gastric adenocarcinoma and was related to the magnitude of lymph node metastasis. N staging is related to survival time of gastric adenocarcinoma. Conclusion 　Overexpression of MMP-9 is likely to a marker of lymph node metastasis in gastric adenocarcinoma. N staging is a pathological parameter in survival time of gast ric adenocarcinoma.