Effect of NO-ASA on Proliferation and the Cell Cycle in Colon Cancer Cells

Objective 　To investigate the effect of NO-ASA on cell proliferation and cell cycle of colon cancer cells. Methods 　Using MTT method, flow cytometry ( FCM), his effect of BPI-1095 on the HCT-8 of proliferation and cell cycle were studied. Results 　The growth of HCT-8 was inhibited by BPI-1095. The inhibition rate of BPI-1095 on HCT-8 cell proliferation increased as incubation time and BPI-1095 concentration increasing ; the cell ratios of S and G₂ phase decreased, whereas the cell ratio of G₁ phase increased with a dose-dependent manner. Conclusion 　BPI-1095 inhibited the growth of colon cancer cells and changed the phase of cell cycle.